Imperial Church and the First Councils
- The Edict of Milan (February 313)
- Constantine’s religious policy: favours to the Church and the emperor’s baptism (313–337) (313–337)
- The Beginning of the Arian Controversy: Arius and Alexander of Alexandria (c. 318–325)
- The Founding of Constantinople, the "New Rome" (324–330)
- The First Ecumenical Council of Nicaea (325)
- Athanasius of Alexandria: Episcopate, Exiles, and Defense of the Nicene Faith (328–373)
- The Council of Serdica (342/343–344)
- Jerome and the Latin Translation of the Bible (the Vulgate) (347–420)
- John Chrysostom: from Antioch to the See of Constantinople and Exile (c. 350–407)
- The Triumph of Homoian Arianism under Constantius II: the Councils of Sirmium and the "Dated Creed" (351–360)
- The Conversion and Baptism of Augustine of Hippo (354–387)
- The Cappadocian Fathers and the Formula "One Ousia, Three Hypostases" (358–381)
- Apollinaris of Laodicea and the Condemnation of His Christology (360–381)
- Julian the Apostate and the Attempt to Revive Paganism (361–363)
- The Council of Alexandria (362) and the Reconciliation of Nicenes and Homoiousians (362)
- Ambrose Becomes Bishop of Milan (373–397)
- The Battle of Adrianople and the Death of Emperor Valens (376–378)
- Theodosius's Edict "Cunctos populos" and the Emperor's Baptism (380)
- The Second Ecumenical Council of Constantinople (May–July 381)
- Augustine as Bishop of Hippo: the "Confessions" and the Doctrine of Grace and Predestination (391–419)
- The Councils of Hippo and Carthage: the Confirmation of the New Testament Canon (393 and 397)
- Ninian and Patrick: the Mission to Scotland and Ireland (394 and 432)
- The Donatist controversy and Augustine's ecclesiology (early 5th c.; council – May 411)
- Symeon Stylites and Syrian monasticism (4th–5th c. (Symeon c. 390–459))
- The Pelagian controversy (from 405 to condemnation at the Council of Ephesus (431); key rulings 411–418)
- The Roman withdrawal from Britain and the Anglo-Saxon conquest (406–409 and after)
- The Vandals: from the Rhine to Carthage, and the sack of Rome (407–455)
- The sack of Rome by Alaric and Augustine's "City of God" (410 (sack of Rome); 412–426 ("City of God"); 430 (death of Augustine))
- Western monasticism: Lérins, John Cassian, and Vincent of Lérins's "Commonitorium" (410 (founding of Lérins) – 434 ("Commonitorium") – 502–542 (Caesarius of Arles))
- The Church of the East ("Nestorian") in Persia: formation and establishment (410 (independence) – 486 (Synod of Seleucia) – 489–507 (school of Nisibis) – 585 (synod))
- The Semi-Pelagian controversy and the Second Council of Orange (529) (5th – early 6th c.; Council of Orange – 529)
- The Nestorian controversy and the Third Ecumenical Council of Ephesus (431); the Union of 433 (428–431 (council – June 431); union of 433 (established by 437–438))
- Leo the Great: pontificate, the doctrine of Roman primacy, and the meeting with Attila (440–461)
- The condemnation of Eutyches and the "Robber Council" of Ephesus (449) (444–450 (council – 8 August 449))